This has made it possible to observe a relation between livedoid vasculopathy and several prothrombotic coagulation defects, such as factor V Leiden gene mutation, protein C or protein S deficiency, prothrombin G20210A gene mutation, anticardiolipin antibodies, hyperhomocysteinemia, or antithrombin III deficiency [4,6,20-25]. This evidence concerns the gene PROS1 and hyperinsulinemic hypoglycemia, familial, 4.