Also, individual knockdown of β-catenin, TCF4, or p68 in Wnt3a-MCF7 cells using respective siRNAs showed that knockdown of any of these molecules resulted in reduced number of colonies, indicating that the tumour-promoting ability of β-catenin not only depends on TCF4 but also on p68 (Figure 6c). The gene discussed is DDX5; the disease is neoplasm.