For instance, in benign lesions such as nevi and neurofibroma, p16INK4a overexpression was associated with senescence [7,8]; whereas in malignancy such as HPV-positive cervical cancer, breast cancer and colorectal adenocarcinoma, it appeared to be associated with high-grade tumors along with RB gene alterations [9-11]. This evidence concerns the gene CDKN2A and breast cancer.