TBX1 and metastatic malignant neoplasm: Nerbil et al. found that early stages colorectal cancer patients (T1-2N0M0, Dukes A) showed a significantly decreased survival when Brachyury was expressed in the tumour tissue while no correlation was observed in later tumour stages, suggesting a possibility to detect metastatic cancers during early stages of colorectal carcinogenesis by using an antibody against brachyury in immunohistochemistry analysis [18].