ZFYVE26 and ocular motility disease: This approach confirmed the diagnosis of Niemann Pick type C in two siblings with adult-onset ataxia, but lacking the characteristic eye movement disorder seen in childhood (Patients P15 and P16), and also prompted careful review of neuroimaging, which confirmed the thin corpus callosum characteristic of ZFYVE26/SPG15 (Patient P19, Fig. 2) (Goizet et al., 2009).