Coagulation parameters were altered in 15/17 patients (88%) including significant decrease of factors IX, XI and XII, and less frequently of antithrombin III, protein C and protein S. Five patients presented blood count abnormalities, i.e. neutropenia (n = 2) or thrombocytopenia (n = 4). This evidence concerns the gene SERPINC1 and Decreased total neutrophil count.