TP53 and B-cell chronic lymphocytic leukemia: The presence at diagnosis of fully clonal genetic lesions that are considered late genetic events in CLL evolution, such as TP53 abnormalities, is already known to have an adverse impact on disease outcome (Zenz et al., 2008, 2010; Dicker et al., 2009; Malcikova et al., 2009; Rossi et al., 2009a; Gonzalez et al., 2011).