TP53 and neoplasm: Most of the co-mutations (connected in red in Figure 6B) are experimentally confirmed by previous studies, including: co-occurrence of 17p13 deletion and TP53 mutations, reflecting a typical two-hit model for tumor suppressor genes; co-occurrence of BIRC3 deletion, 11q22-q23 deletion, and BIRC3 mutations; and the relationship between NOTCH1 mutations and +12 (Balatti et al., 2012; Del Giudice et al., 2012).