On analysis of metabolism-related protein expression in the stromal compartment of tumors, the expression of MCT4 (p = 0.002), GLS1 (p = 0.006), GDH (p = 0.035), SDHA (p = 0.004), PHGDH (p = 0.018), PSPH (p = 0.006), PSAT1 (p < 0.001), and SHMT1 (p < 0.001) showed site specificity: higher stromal expression of MCT4, GLS1, GDH, SDHA, PHGDH, and SHMT1 were found in bone metastasis, while PSPH and PSAT1 were higher in brain metastasis (Table 4). This evidence concerns the gene SHMT1 and bone metastasis.