At T1, upregulated genes were mostly enriched in Soluble NSF Attachment Protein receptor (SNARE) interactions in vesicular transport, asthma, graft-versus-host disease, melanogenesis, and p53 signaling pathway, while downregulated genes at T1 were significantly enriched in chemokine signaling pathway (Table 1). This evidence concerns the gene TP53 and graft versus host disease.