To our knowledge, this is the first study to test human bNAbs individually and in pair-wise combinations against a panel of clade B T/F viruses; among them, three T/F virus strains, REJO.c, RHPA.c and THRO.c, were juxtaposed with pseudoviruses with early infection env genes derived from the same patients, respectively. This evidence concerns the gene ERVW-1 and infection.