GNRH1 and irritable bowel syndrome: A subgroup of patients treated with gonadotropin-releasing hormone (GnRH) analogs develops enteric neuropathy with reduced relative number of GnRH-containing neurons and dysmotility [1,2], and increased abdominal pain and exacerbation of irritable bowel syndrome (IBS) has been observed in a cohort of GnRH-treated women at follow-up, although no obvious dysmotility was at hand [3].