Interestingly, one study has shown that an increased oxidative stress observed in olfactory neurosphere-derived cells from PD patients could be restored by activation of Nrf2 with sulforaphane [12] and curcumin has been shown to protect DAergic SH-SY5Y neurons from 6-Hydroxydopamine toxicity [13]. This evidence concerns the gene NFE2L2 and Parkinson disease.