KLK3 and Familial prostate cancer: They went on to analyse the most promising candidate miRNAs from their screening study (miR-141, miR-375, and miR-200b) in a larger cohort of patients (n = 45), and found that miR-375 and miR-141 levels could distinguish high-risk (Gleason grade ≥ 8 or metastases) from Gleason 7 prostate cancers with greater accuracy than PSA.