HIF1A and cancer: For the HIF-1α C1772T polymorphism, the overall results from the eligible studies demonstrated a significant association between the HIF-1α C1772T polymorphism and an increased cancer risk in four genetic models (TT vs. CC: OR = 1.63, 95% CI = 1.02-2.60; CT + TT vs. CC: OR = 1.15, 95% CI = 1.01-1.34; TT vs. CT + CC: OR = 2.11, 95% CI = 1.32-3.77; T vs. C: OR = 1.21, 95% CI = 1.04-1.41).