TP53 and neoplasm: The study reported by Putra et al. indicated that even though they did not found any significant differences in genotype for G1790A between lung cancer patients and healthy controls, however, the G1790A variant allele was significantly higher in lung cancer patients, and TP53 LOH and 1p34 LOH were more frequently observed in individuals with the HIF-1α G1790A polymorphism, suggesting that this polymorphism may induce mutations in some tumor suppressor genes involved in lung cancer development [46].