In the subgroup analysis by cancer type, the HIF-1α C1772T polymorphism significantly increased the risk of breast cancer in Asians (TT vs. CC: OR = 4.42, 95% CI = 1.60-12.21; TT vs. CT + CC: OR = 4.16, 95% CI = 1.51-11.48; T vs. C: OR = 1.28, 95% CI = 1.05-1.55), other cancers (TT vs.CC: OR = 3.18, 95% CI = 1.90-5.32; TT vs. CT + CC: OR = 3.31, 95% CI = 1.98-5.53; T vs. C: OR = 1.47, 95% CI = 1.10-1.96) and lung cancer (TT vs. CT + CC: OR = 3.27, 95% CI = 1.73-6.17 ). The gene discussed is HIF1A; the disease is lung carcinoma.