For HIF-1α G1790A polymorphism, as shown in Table 3, the association between the HIF-1α G1790A polymorphism and increased cancer risk was significant for the pooled ORs under all of the genetic models (AA vs. GG: OR = 5.11, 95% CI = 2.08-12.56; GA vs. GG: OR = 1.45, 95% CI = 1.05-1.99; AA + AG vs. GG: OR = 1.63, 95% CI = 1.16-2.30; AA vs. GA + GG: OR = 4.41, 95% CI = 1.80-10.84; A vs. G: OR = 1.77, 95% CI = 1.23-2.25). The gene discussed is HIF1A; the disease is cancer.