In this respect, we sought to incorporate in our analysis not only the traditional confounders (such as age, systolic blood pressure, diabetes, dyslipidemia) but also more transplant-specific factors that have been previously connected to AIx (donor age [26], magnesemia [27] or cardiovascular complications (aortic calcification [24], CMV replication [28], CD4+ lymphopenia [29]). This evidence concerns the gene CD4 and lymphopenia.