In contrast, the following variables turned out to be not significantly associated with AIx: albuminuria, diabetes and smoking status, LDL and HDL cholesterol, C reactive protein, vitamin D, familial history of cardiovascular diseases, renin-angiotensin system blockers, calcineurin use and systemic exposure, use of steroids, history of chronic rejection, CD4+ lymphopenia, CMV replication. The gene discussed is REN; the disease is diabetes mellitus.