Despite down-regulation of CXCR3 for several hours post-desensitization, no difference in migration to the tumours was observed when compared with the untreated cells (Fig.5b–d), suggesting that although CXCR3+ T cells are enriched within tumour immigrants, CXCR3-expression is not required for migration to occur. The gene discussed is CXCR3; the disease is neoplasm.