INS and Insulin resistance: In addition to FHBL2 phenotype also plasma NEFAs (non-esterified fatty acids), insulin, fasting plasma glucose and HOMA-IR (homoeostatic model assessment of insulin resistance) values are significantly lower in individuals homozygous for S17X mutation compared with carriers and non-carriers [14,15] linking the hypolipidaemic effect of ANGPTL3-deficiency with insulin sensitivity.