PRKDC is also thought to be required for transcriptional regulation mediated by transcription factors, such as lymphocyte enhancer factor 1 (LEF1) [69], heat shock transcription factor (HSF) [70], p53 and the product of the predominant ETS gene fusion, TMPRSS2:ERG, in prostate cancer [71]. Here, LEF1 is linked to Familial prostate cancer.