Comparing between patients with undetectable and detectable CSF levels of IL-1β at baseline, we found that mean Progression Index (PI) and MS Severity Scale (MSSS) were significantly lower among subjects with undetectable IL-1β (PI: 0.19 ± 0.1 versus 0.29 ± 0.2; MSSS: 2.26 ± 2.1 versus 3.41 ± 2.6, p < 0.01 for both parameters). Here, IL1B is linked to myeloid sarcoma.