TYMS and non-small cell lung carcinoma: Thus, the observed superior clinical effectiveness associated with pemetrexed treatment in our study should be further evaluated for their potential impact on overall survival in Chinese patients using a better study design and the possible predictive roles of age, platinum agent, thymidylate synthase, and Chinese ethnicity for the treatment response to pemetrexed in the first-line setting for advNS-NSCLC should be further investigated to guide future clinical practices.