The detection of two novel pathogenic RP1 variants p.Ile1528Valfs*10 and p.Ile1988Asnfs*3 suggests that the use of IRD panels of a small size, limited to prevalent genes of a particular population, together with an optimized data analysis pipeline, is an efficient and cost-effective approach for the diagnosis of diverse retinal disorders. Here, RP1 is linked to retinal disorder.