Furthermore, Fibulin-5 mRNA levels were down-regulated in HCC cell lines, Hep3B, HepG2, MHCC97L, SMMC-7721, MHCC97H and HCC-LM3, as compared with that in normal hepatocyte cell line, LO2 (P < 0.05, Figure 1B). Here, FBLN5 is linked to hepatocellular carcinoma.