As shown in Table 1, low expression of Fibulin-5 protein was prominently associated with multiple tumor nodes (P = 0.001), venous infiltration (P = 0.011), high Edmondson-Steiner grading (P = 0.014) and advanced tumor-node-metastasis (TNM) tumor stage (P = 0.033). The gene discussed is FBLN5; the disease is neoplasm.