Blocking IL-17RA or RC signaling significantly inhibited asthmatic B cell migration induced by IL-17A (RA: p = 0.009; RC: p = 0.011), IL-17F (RA: p = 0.002; RC: p = 0.0005), or IL-17A+F (RA: p = 0.0002; RC: p = 0.0003), compared to Ig isotype control which had no effect on B cell migration. The gene discussed is IL17RA; the disease is rheumatoid arthritis.