Genetic studies have shown that LQTS is caused by pathogenic mutations in 15 genes encoding cardiac ion channels or membrane adaptors (KCNQ1, KCNH2, SCN5A, ANK2, KCNE1, KCNE2, KCNJ2, CACNA1C, CAV3, SCN4B, AKAP9, SNTA1, RYR2, KCNJ5 and SCN1B) [3]. This evidence concerns the gene SCN5A and familial long QT syndrome.