Sestrin 1 (SESN1), a putative tumor suppressor and mTOR signaling inhibitor [25], was identified as a gene synergistically up-regulated commonly in 3 of 4 EZH2 mutant cells with combination treatment, but not in EZH2 wild-type cells (Fig. 4A and table 2). The gene discussed is MTOR; the disease is neoplasm.