Our studies have also demonstrated an association of the polymorphism rs2336691 with CAD, which is located in the intron 1 of DNMT1. According to the NCBI dbSNP data base (National Center for Biotechnology Information, Bethesda, MD, USA), MAF (minor allele frequency) of this locus in CHB population is very low (around 0.06); however, in this study, the frequency of minor A allele accounted for 14% (Table 2). Here, DNMT1 is linked to coronary artery disorder.