Obesity is the consequence of an augment in adipose tissue, with accompanying alteration of the immune response, resulting in an increase in the number of macrophages in the AT, insulin resistance and hyperinsulinemia, elevated NEFA levels as well as elevated pro- inflammatory mediators (IL-1, IL-6 y TNF-α) [44-46]. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.