Moreover, the shift from classic (involved largely in phagocytosis and preferentially producing the immunosuppressive cytokine, interleukin 10) to proinflammatory intermediate monocytes (known to possess the highest expression of surface markers for antigen processing and presentation and produce the highest amounts of proinflammatory cytokines) probably represents a response to the inflammatory milieu present in the CNS during CM-IRIS. The gene discussed is IL10; the disease is cutaneous mastocytosis.