CD14 and infection: Consistent with these differences, the classic subset (CD14++CD16−) comprised 86% of monocytes in blood (IQR, 83%–89%) but only 13% (IQR, 0%–28%) in CSF; intermediate monocytes had higher frequencies in CSF than in blood, suggesting that IRIS represents a localized response at the site of infection rather than a more generalized response to ART (Figure 4).