Aerosol infection of mice with Cryptococcus spores elicits a self-limited subclinical pneumonia, accompanied sequentially by local recognition of the fungus by alveolar macrophages and neutrophils, then by monocytes and finally expansion of Cryptococcus-specific CD4+ and CD8+ T cells [7, 8], which parallels the immunopathogenesis in the cerebrospinal fluid (CSF) with meningitis [9]. This evidence concerns the gene CD4 and infection.