HMGA2 and breast cancer: In the breast cancer MDA-MB-231 cell model, histone H3 K4me3 and K27me3 modifications did not change at all after silencing of HMGA2 (Supplementary Figure S4A (iii, v)); however, reproducible and significant but weak increases in binding of histone H3 K9ac (and K9me3) were observed in MDA-shHmga2 cells (Supplementary Figure S4A (iv, vi)), which correlate with the observed 8-fold induction of CDH1 mRNA levels after HMGA2 silencing (Figure 3F).