In the present study we show that the expression of the transcription co-factor proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) and downstream mitochondrial antioxidant enzymes peroxiredoxin-3 (Prx3) and thioredoxin-2 (Trx2) is markedly increased in astrocytes in active multiple sclerosis (MS) lesions. This evidence concerns the gene PRDX3 and multiple sclerosis.