CD4 and infection: A Kv1.3 knock-out induced EAE mouse model of infection showed that CD4+ T cells expressed greater levels of IL-10 and lower levels of IL-17 and IFN-γ, and suppressed proliferation of wild-type CD4+ T cells, suggesting a skewing toward a regulatory phenotype [48], although an increase in the number of Foxp3+ cells was not observed.