However, when we focused our analysis on patients treated with immune biologics only after primary resection, and therefore as primary adjuvant therapy, higher primary melanoma MMP-23 expression was associated with increased recurrence, as recurrence was detected in 1/4 (25%) patients with low melanoma MMP-23 expression, compared with 13/15 (87%) patients with high melanoma MMP-23 expression (P = 0.037). The gene discussed is MMP23B; the disease is melanoma.