MMP23B and melanoma: Considering the entire cohort of patients – receiving immunotherapy after primary resection or at recurrence – subsequent recurrence was detected in 11/19 (59%) patients with low melanoma MMP-23 expression (composite score = 0–2) compared with 42/52 (81%) patients high melanoma MMP-23 expression (composite score = 3–4) (P = 0.067) (Table 3).