The 3 mg dose of LCI699 inhibited 11β-hydroxylase on Day 6 (as demonstrated by both an attenuated cortisol response to ACTH and increase in 11-deoxycortisol) and also resulted in a small increase in plasma potassium which, in conjunction with the clinical observations, suggested development of mild hypoaldosteronism. This evidence concerns the gene POMC and Decreased circulating aldosterone concentration.