SERPINE1 and type 2 diabetes mellitus: Acosta et al. [47] showed that ADSC obtained from patients with T2DM have less fibrinolytic ability as they secreted more PAI-1 and less tissue activator of plasminogen and D-dimer, which leads to the development of microtrombotic complications of cell therapy using these cells for the treatment of critical low limb ischemia [47].