As shown in Table 2 and Figure 2, ULR models of SSc patients with BoPAP versus normal mPAP identified the following variables as being statistically significant predictors of BoPAP (P <0.05): older age, presence of peripheral edema, a higher log10 NT-proBNP, greater left atrium diameter, and greater tricuspid regurgitation (TR) velocity. The gene discussed is NPPB; the disease is Tricuspid regurgitation.