Inhibition of Wnt/β-catenin signaling by silencing LRP6 or TBL1X prevented the promoted miR-610-inhibitor-induced proliferative rates and the anchorage-independent growth ability (Figure 7C and D), as well as the expression of Cyclin D1 and c-Myc (Figure 7E), suggesting that LRP6 and TBL1X involved in miR-610 inhibiton-induced proliferation and tumorigenicity of HCC cells. This evidence concerns the gene TBL1X and hepatocellular carcinoma.