Straussman and colleagues demonstrated that the HGF-mediated rescue of melanoma cellsfrom drug sensitivity was mediated through HGF's cognate receptor tyrosine kinase MET bytreating melanoma cell lines co-cultured with stromal cell lines in the presence ofPLX4720 with the MET inhibitor crizotinib, as shown in Figure 2D and Supplemental Figure11. The gene discussed is NTRK1; the disease is melanoma.