HGF and melanoma: To date, a direct replication has been reported; Lezcano and colleagues (Lezcano et al., 2014) published a replication ofFigure 3 of Straussman et al. Nature 2013, wherein Straussman and colleagues evaluatedHGF expression in patient-derived primary melanoma samples and observed a negativecorrelation between expression of HGF and response to therapy (Straussman et al., 2012).