NFE2L2 and cancer: High concentrations of glucosinolates are linked with a number of distinct cancer chemopreventive mechanisms, including the induction of antioxidant and detoxification genes through the activation of nuclear factor erythroid 2-related factor 2 and aryl hydrocarbon receptor, inhibition of pro-inflammatory reactions by repression of nuclear factor-kappa B, inhibition of CYP enzyme activity, inhibition of histone deacetylase, and stimulation of cell cycle arrest and apoptosis[18].