This is comparable to data shown by Liu et al., who found that GDF15 inhibits migration of prostate cancer cells and reduces cell adhesion but has no impact on tumor cell proliferation.40 A higher GDF15 level in the A2780cis cells might therefore suppress the migration of the A2780cis cells in vitro, while knockdown of GDF15 led to an enhanced migratory potential and altered colony formation of these cells. This evidence concerns the gene GDF15 and neoplasm.