However, after 7 days post infection virus-specific CD8+ T-cells re-expressed CD73 and at 21 days post infection epitope specific CD8+ T-cells began to diverge in expression level, with M45-specific CD8+ T-cells expressing high levels of CD73 and the inflationary M38-specific CD8+ T-cells reaching similar levels of expression to that of naïve CD8+ T-cells. The gene discussed is NT5E; the disease is infection.