HGF and Cafe-au-lait spot: In addition, in various congenital hyperpigmented disorders such as systemic scleroderma, dermatofibroma, café-au-lait macules of neurofibromatosis, and generalized progressive dyschromatosis, an increase in the production of growth factors known to be melanogenic has been reported in the dermal compartment; these factors include SCF, hepatocyte growth factor (HGF) or keratinocyte growth factor (KGF) [17]–[21].