Furthermore, although high circulating levels of the pro-inflammatory molecule CRP, a major component of the innate immune system in humans, is associated with the development and progression of native atherosclerosis and CAV, another component of the innate immune system, immunoglobulin (Ig) M and/or IgG natural antibodies (NAbs), may convey an atheroprotective function since high titers of IgM and/or IgG NAbs have been associated with reduced atherosclerosis and low levels are associated with reduced vein graft plaque in mice [49] and reduced atherosclerosis in mice and humans [50]–[55]. This evidence concerns the gene CRP and atherosclerosis.