DIRAS3 and neoplasm: In this paper, Migdalska-Sek at al. assessed and compared the methylation level of 8 tumor suppressor genes, ARHI, CDH1, KCNQ1, MEST, p16INK4A, RASSF1A, SLC5A8 and VHL in PTC tumor tissues and matched adjacent noncancerous thyroid tissues [71].