There were no associations between prostate cancer risk and 212 SNPs from 12 genes related to vitamin D (including CYP27A1, VDBP, CYP27B1, CYP24A1, VDR) examined in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial (749 incident cases, 781 controls) [23]. The gene discussed is CYP27A1; the disease is Familial prostate cancer.