There was evidence of an association of linked VDBP SNPs rs4588-A and rs7041-T, representing low levels of 25(OH)D, with prostate cancer risk (rs4588: OR 1.20, 95 % CI 1.01, 1.41, p = 0.04; rs7041: OR 1.19, 95 % CI 1.02, 1.38, p = 0.03). This evidence concerns the gene GC and prostate carcinoma.