LOXL4 and neoplasm: For example, PIM1 is an ER regulated proto-oncogene that has been shown to play a role in BCa cell proliferation, migration and metastasis and is associated with high grade tumours (37,38); KRT13 has been associated with BCa cell growth and metastasis (39) and LOXL4 is an established promoter of cell invasion (40–42) (Supplementary Figure S2D).