Consistent with our array studies we note that there was a highly significant induction of CCNG2, Cited2 and BRCA1 with the most potent induction being observed for CCNG2. This response was conserved between the MCF-7 breast cancer cell line (as we would predict based on our array studies) as well as the U2OS osteosarcoma cell line (data not shown). This evidence concerns the gene BRCA1 and osteosarcoma.