While FBP-knockdown (FBP-kd) significantly activated p53 transcription activity, transient expression of FBP1 in FBP-kd Huh7 cells restored the control phenotype inhibiting p53 functions suggesting a novel mechanism by which p53 is impaired in this cell line with the implication in the development of HCC tumor. This evidence concerns the gene TP53 and hepatocellular carcinoma.