Given that SUV39H2 is significantly upregulated in various types of tumour tissues (Supplementary Table 1), it is possible that constitutive SUV39H2 overexpression in cancer cells may cause aberrant γ-H2AX expression, and that cancer cells might acquire more malignant phenotype, including chemo- and/or radioresistance. Here, SUV39H2 is linked to neoplasm.