It had also been identified as a contributing factor in the development of lymphoproliferative diseases in a murine model of autoimmunity, where raised counts of CD4+ T cells with an activated phenotype were noted (Balashov et al. 1997; Gandhi et al. 2013; Juntilla and Koretzky 2008; Xiao et al. 2008). The gene discussed is CD4; the disease is Autoimmunity.