However, the previously reported cancer-associated variants show only weak LD with rs13174814 (r2 < 0.07 for all comparisons) (Supplementary Table 5), suggesting that this SNP represents a novel risk variant for cancer in the promoter region of TERT. The other SNP independently associated with endometrial cancer, rs62329728 (OR = 1.27, CI = 1.14–1.43, P = 2.2 × 10−5), maps to a non-coding region ~12 kb upstream of the 5′ UTR of CLPTM1L (Supplementary Fig. 1c). Here, CLPTM1L is linked to cancer.