Unlike previous studies in hormone-related malignancies (breast, ovarian and prostate), which only found risk variants in or near TERT, our study found evidence of risk variants in and near TERT and also near CLPTM1L. Future studies should investigate the functional effects of prioritized risk-associated variants on CLPTM1L and/or TERT in endometrial cancer and other cancer models. Here, CLPTM1L is linked to cancer.