However, in our study we found that phosphorylation of NFκB was insensitive to GSK3 inhibition in NSCLC cell lines sensitive to CHIR99021, suggesting GSK3 activity on NFκB is unlikely to be involved in the affect of the kinase on NSCLC cell proliferation/viability. The gene discussed is NFKB1; the disease is non-small cell lung carcinoma.