It is of interest to note that NFκB, one of the GSK3 substrates used here as an indicator of GSK3 activity, is a transcription factor involved in the regulation of cell proliferation, differentiation and apoptosis, is deregulated in many tumours [39] and can be activated through phosphorylation of the p65-RelA subunit by GSK3 [40]. This evidence concerns the gene NFKB1 and neoplasm.